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Mild method for the synthesis of amidines by the electrophilic activation of amides

✍ Scribed by André B Charette; Michel Grenon

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
125 KB
Volume
41
Category
Article
ISSN
0040-4039

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✦ Synopsis

The synthesis of amidines was achieved by the addition of amines to amides that were previously activated with trifluoromethanesulfonic anhydride (triflic anhydride) and pyridine. Various disubstituted and trisubstituted amidines were prepared in yields up to 84%.

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