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A new mild method for the synthesis of amidines

✍ Scribed by Udo E.W. Lange; Bernd Schäfer; Dorit Baucke; Ernst Buschmann; Helmut Mack

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
226 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis

A new method for the synthesis of amidines is presented using N-acetylcysteine as a catalyst. The key advantage of this new method is that it is compatible with a large number of functional groups. It allows the synthesis of amidines in complex molecules containing acid-labile groups, base-labile centers of asymmetry or functional groups sensitive to hydrogenation.

📜 SIMILAR VOLUMES

Mild method for the synthesis of amidine
Mild method for the synthesis of amidines by the electrophilic activation of amides
✍ André B Charette; Michel Grenon 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 125 KB

The synthesis of amidines was achieved by the addition of amines to amides that were previously activated with trifluoromethanesulfonic anhydride (triflic anhydride) and pyridine. Various disubstituted and trisubstituted amidines were prepared in yields up to 84%.