Role of tumor necrosis factor-α in the regulation of activated synovial T cell growth: Downregulation of synovial T cells in rheumatoid arthritis patients
✍ Scribed by Ning-Sheng Lai; Joung-Liang Lan; Chia-Li Yu; Rong-Hwa Lin
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 658 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0014-2980
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📜 SIMILAR VOLUMES
Synovial fluids from 6 of 12 patients with rheumatoid arthritis (RA) and from 3 of 11 patients with reactive arthritis contained measurable levels of tumor necrosis factor a (TNFa). Seven of 12 sera from RA patients contained TNFa, while only 1 of those from reactive arthritis patients was positive.
## Abstract Markedly elevated levels of T cells expressing Ia antigens were found in the synovial membranes and synovial fluids of patients with rheumatoid arthritis. The primary increase in expression of the la antigens was on the OKT 8+ (suppressor/cytotoxic) T cell subset. In addition, the total