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Detection of tumor necrosis factor α but not tumor necrosis factor β in rheumatoid arthritis synovial fluid and serum

✍ Scribed by T. Saxne; M. A. Palladino Jr; D. Heinegãrd; N. Talal; F. A. Wollheim

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
386 KB
Volume
31
Category
Article
ISSN
0004-3591

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✦ Synopsis

Synovial fluids from 6 of 12 patients with rheumatoid arthritis (RA) and from 3 of 11 patients with reactive arthritis contained measurable levels of tumor necrosis factor a (TNFa). Seven of 12 sera from RA patients contained TNFa, while only 1 of those from reactive arthritis patients was positive. Gamma-interferon was detected in the synovial fluids and sera of only the RA patients. Tumor necrosis factor /3 was not detected in any sera or synovial fluids. RA patients with detectable TNFa had higher erythrocyte sedimentation rates and synovial fluid leukocyte counts.

In some cases, inflammatory joint disease may result in erosive destruction of cartilage and bone, whereas in other cases, the process may heal and leave the joint structures intact. The basic pathogenetic differences between destructive rheumatoid arthritis (RA) and nondestructive reactive arthritis are not

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## Abstract ## Objective Treatment of rheumatoid arthritis (RA) with tumor necrosis factor (TNF)–blocking agents, including etanercept and infliximab, has resulted in reductions in the radiographic progression of RA. However, the exact mechanism by which this protection occurs has not been determi