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Role of the intracellular localization of HIF-prolyl hydroxylases

✍ Scribed by Ken-ichi Yasumoto; Yusuke Kowata; Atsushi Yoshida; Satoru Torii; Kazuhiro Sogawa

Book ID
113486278
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
590 KB
Volume
1793
Category
Article
ISSN
0167-4889

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## Abstract Hypoxia and induction of hypoxia‐inducible factors (HIF‐1Ξ± and HIF‐2Ξ±) is a hallmark of many tumors. Under normal oxygen tension HIF‐alpha subunits are rapidly degraded through prolyl hydroxylase dependent interaction with the von Hippel‐Lindau (VHL) tumor suppressor protein, a componen