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Determination and comparison of specific activity of the HIF-prolyl hydroxylases

✍ Scribed by Jason R. Tuckerman; Yuguang Zhao; Kirsty S. Hewitson; Ya-Min Tian; Christopher W. Pugh; Peter J. Ratcliffe; David R. Mole


Book ID
116464881
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
343 KB
Volume
576
Category
Article
ISSN
0014-5793

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Regulation of HIF prolyl hydroxylases by
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## Abstract Hypoxia and induction of hypoxia‐inducible factors (HIF‐1Ξ± and HIF‐2Ξ±) is a hallmark of many tumors. Under normal oxygen tension HIF‐alpha subunits are rapidly degraded through prolyl hydroxylase dependent interaction with the von Hippel‐Lindau (VHL) tumor suppressor protein, a componen