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Gallate, the component of HIF-inducing catechins, inhibits HIF prolyl hydroxylase

✍ Scribed by Fuyo Tsukiyama; Yumi Nakai; Masataka Yoshida; Takahiro Tokuhara; Kiichi Hirota; Akiko Sakai; Hideyuki Hayashi; Takahiro Katsumata

Book ID
116293802
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
342 KB
Volume
351
Category
Article
ISSN
0006-291X

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Regulation of HIF prolyl hydroxylases by
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## Abstract Hypoxia and induction of hypoxia‐inducible factors (HIF‐1Ξ± and HIF‐2Ξ±) is a hallmark of many tumors. Under normal oxygen tension HIF‐alpha subunits are rapidly degraded through prolyl hydroxylase dependent interaction with the von Hippel‐Lindau (VHL) tumor suppressor protein, a componen