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Catalytic mechanism and substrate specificity of HIF prolyl hydroxylases

✍ Scribed by Smirnova, N. A.; Hushpulian, D. M.; Speer, R. E.; Gaisina, I. N.; Ratan, R. R.; Gazaryan, I. G.

Book ID
119881464
Publisher
Springer
Year
2012
Tongue
English
Weight
484 KB
Volume
77
Category
Article
ISSN
0006-2979

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## Abstract Hypoxia and induction of hypoxia‐inducible factors (HIF‐1Ξ± and HIF‐2Ξ±) is a hallmark of many tumors. Under normal oxygen tension HIF‐alpha subunits are rapidly degraded through prolyl hydroxylase dependent interaction with the von Hippel‐Lindau (VHL) tumor suppressor protein, a componen