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Role of the C3b-binding site on C4b-binding protein in regulating classical pathway C5 convertase

✍ Scribed by Nenoo Rawal; Michael K. Pangburn

Book ID
116756212
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
399 KB
Volume
44
Category
Article
ISSN
0161-5890

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Role of the C3b-binding site on C4b-bind
Role of the C3b-binding site on C4b-binding protein in regulating classical pathway C5 convertase
✍ Nenoo Rawal; Michael K. Pangburn πŸ“‚ Article πŸ“… 2007 πŸ› Elsevier Science 🌐 English βš– 399 KB

A high affinity C5 convertase is generated when a C3 convertase deposits additional C3b molecules on and around itself thereby switching the substrate specificity of C3 convertase from C3 to C5. In the present study the role of the additional C3b molecules in influencing the regulation of classical