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Monoclonal anti-human C4b antibodies: Stabilization and inhibition of the classical-pathway C3 convertase

โœ Scribed by Ichihara Chikako; Nakamura Tohru; Nagasawa Shigeharu; Koyama Jiro


Book ID
119089563
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
853 KB
Volume
23
Category
Article
ISSN
0161-5890

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Role of the C3b-binding site on C4b-bind
โœ Nenoo Rawal; Michael K. Pangburn ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 399 KB

A high affinity C5 convertase is generated when a C3 convertase deposits additional C3b molecules on and around itself thereby switching the substrate specificity of C3 convertase from C3 to C5. In the present study the role of the additional C3b molecules in influencing the regulation of classical