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Stringent regulation of complement lectin pathway C3/C5 convertase by C4b-binding protein (C4BP)

✍ Scribed by Nenoo Rawal; Rema Rajagopalan; Veena P. Salvi


Book ID
116757517
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
512 KB
Volume
46
Category
Article
ISSN
0161-5890

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Role of the C3b-binding site on C4b-bind
✍ Nenoo Rawal; Michael K. Pangburn πŸ“‚ Article πŸ“… 2007 πŸ› Elsevier Science 🌐 English βš– 399 KB

A high affinity C5 convertase is generated when a C3 convertase deposits additional C3b molecules on and around itself thereby switching the substrate specificity of C3 convertase from C3 to C5. In the present study the role of the additional C3b molecules in influencing the regulation of classical