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Determination of the solution structure of part of the binding site for C4b on C4b-binding protein by NMR

โœ Scribed by Lena Kask; Huw T. Jenkins; Andrew P. Herbert; Paul N. Barlow


Book ID
116756040
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
76 KB
Volume
44
Category
Article
ISSN
0161-5890

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A high affinity C5 convertase is generated when a C3 convertase deposits additional C3b molecules on and around itself thereby switching the substrate specificity of C3 convertase from C3 to C5. In the present study the role of the additional C3b molecules in influencing the regulation of classical