✦ LIBER ✦

Role of CRMP-2 in neuronal polarity

✍ Scribed by Arimura, Nariko ;Menager, Celine ;Fukata, Yuko ;Kaibuchi, Kozo

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 324 KB
Volume: 58
Category: Article
ISSN: 0022-3034
DOI: 10.1002/neu.10269

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Of the several types of polarized cells, the neuron is one of the most dramatic examples. It extends two distinctive processes, axon and dendrite. Polarization in neurons enables the two processes to play their functionally different roles, sending and receiving electrical signals in a vectorial fashion. While a catalog of structural, molecular, and functional differences between axon and dendrite is accumulating, the mechanisms involved in establishment of neuronal polarity are not well understood. Neuronal polarity formation begins with the elongation of one process as an axon in a symmetric cell phase. In this review, we describe recent advances in the understanding of several cellular events in the early development of axon and dendrite. We also discuss the involvement of the Rho family small GTPases, their upstream and downstream molecules, and collapsin response mediator protein‐2 (CRMP‐2) in the regulation of neuronal polarity. © 2003 Wiley Periodicals, Inc. J Neurobiol 58: 34–47, 2004

📜 SIMILAR VOLUMES

Role of caspases in neuronal apoptosis

✍ Roseann Ventimiglia; Lit-Fui Lau; Ross A. Kinloch; Andrew Hopkins; Eric H. Karra 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 213 KB

Development of polarity in cerebellar gr

Development of polarity in cerebellar granule neurons

✍ Powell, Sharon K. ;Rivas, Rodolfo J. ;Rodriguez-Boulan, Enrique ;Hatten, Mary E. 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 290 KB 👁 1 views

Axon formation in developing cerecell surface distribution of a specific class of endogebellar granule neurons in situ is spatially and temponous glycoproteins, those linked to the membrane by rally segregated from subsequent neuronal migration a glycosylphosphatidyl inositol (GPI) anchor, was also

Implication of Wnt signaling in neuronal

Implication of Wnt signaling in neuronal polarization

✍ Guo-Ying Yang; Zhen-Ge Luo 📂 Article 📅 2011 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 272 KB

## Abstract Wnt ligands comprise a large family of secreted glycoproteins that control a variety of developmental processes including cell polarization in diverse organisms. Through various receptors present on receiving cells, Wnts initiate intracellular signaling cascades resulting in changes in

Protein product of CLN6 gene responsible

Protein product of CLN6 gene responsible for variant late-onset infantile neuronal ceroid lipofuscinosis interacts with CRMP-2

✍ Jared W. Benedict; Amanda L. Getty; Thomas M. Wishart; Thomas H. Gillingwater; D 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 376 KB

## Abstract Mutations in __CLN6__ cause variant late‐onset neuronal ceroid lipofuscinosis (vLINCL), a childhood neurodegenerative disorder resulting from aberrant neuronal cell loss and pathological accumulation of lysosomal autofluorescent storage material in the central nervous system. The direct

Role of c-Jun concentration in neuronal

Role of c-Jun concentration in neuronal cell death

✍ Oliver G. Rössler; Lars Steinmüller; Klaus M. Giehl; Gerald Thiel 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 283 KB

## Abstract A dimer of the basic region leucine zipper proteins c‐Jun and c‐Fos constitutes the classical activator protein‐1 (AP‐1) transcription factor. c‐Jun is thought to play essential roles in many important cellular pathways, including the control of proliferation and cell death. To investig

On the Role of Subthreshold Dynamics in

On the Role of Subthreshold Dynamics in Neuronal Signaling

✍ John R. Clay; Alvin Shrier 📂 Article 📅 1999 🏛 Elsevier Science 🌐 English ⚖ 177 KB

The role of subthreshold dynamics in neuronal signaling is examined using periodic pulse train stimulation of the Fitzhugh-Nagumo (FN) model of nerve membrane excitability and results from the squid giant axon as an experimental data base. For a broad range of stimulus conditions the first pulse in