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Implication of Wnt signaling in neuronal polarization

✍ Scribed by Guo-Ying Yang; Zhen-Ge Luo


Publisher
Wiley (John Wiley & Sons)
Year
2011
Tongue
English
Weight
272 KB
Volume
71
Category
Article
ISSN
1932-8451

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✦ Synopsis


Abstract

Wnt ligands comprise a large family of secreted glycoproteins that control a variety of developmental processes including cell polarization in diverse organisms. Through various receptors present on receiving cells, Wnts initiate intracellular signaling cascades resulting in changes in gene transcription or cytoskeleton reorganization. Recently, several lines of evidence have suggested the role of Wnt signaling in establishing axon–dendrite polarity in developing neurons. In this review, we summarize the recent results related with the role of Wnt signaling in neuronal polarization. Β© 2010 Wiley Periodicals, Inc. Develop Neurobiol 71: 495–507, 2011


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