## Abstract Although it is well known that Wnt and protein kinase C (PKC) signaling pathways are both involved in carcinogenesis and tumor progression, their synergistic contribution to these processes or the crosstalk between them has just recently been approached. The Wnt and PKC signaling are in
Implication of Wnt signaling in neuronal polarization
β Scribed by Guo-Ying Yang; Zhen-Ge Luo
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 2011
- Tongue
- English
- Weight
- 272 KB
- Volume
- 71
- Category
- Article
- ISSN
- 1932-8451
No coin nor oath required. For personal study only.
β¦ Synopsis
Abstract
Wnt ligands comprise a large family of secreted glycoproteins that control a variety of developmental processes including cell polarization in diverse organisms. Through various receptors present on receiving cells, Wnts initiate intracellular signaling cascades resulting in changes in gene transcription or cytoskeleton reorganization. Recently, several lines of evidence have suggested the role of Wnt signaling in establishing axonβdendrite polarity in developing neurons. In this review, we summarize the recent results related with the role of Wnt signaling in neuronal polarization. Β© 2010 Wiley Periodicals, Inc. Develop Neurobiol 71: 495β507, 2011
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