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Role of Biotransformation Studies in Minimizing Metabolism-Related Liabilities in Drug Discovery

✍ Scribed by Yue-Zhong Shu; Benjamin M. Johnson; Tian J. Yang

Book ID
111767473
Publisher
American Association of Pharmaceutical Scientists
Year
2008
Tongue
English
Weight
335 KB
Volume
10
Category
Article
ISSN
1550-7416

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## Abstract Metabolism by the host organism is one of the most important determinants of the pharmacokinetic profile of a drug. High metabolic lability usually leads to poor bioavailability and high clearance. Formation of active or toxic metabolites will have an impact on the pharmacological and t