Role of drug metabolism in drug discover
✍
Gondi N. Kumar; Sekhar Surapaneni
📂
Article
📅
2001
🏛
John Wiley and Sons
🌐
English
⚖ 300 KB
👁 1 views
## Abstract Metabolism by the host organism is one of the most important determinants of the pharmacokinetic profile of a drug. High metabolic lability usually leads to poor bioavailability and high clearance. Formation of active or toxic metabolites will have an impact on the pharmacological and t