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Enzyme Inhibition in Drug Discovery and Development || The Role of Drug Metabolism in Drug Discovery

โœ Scribed by Lu, Chuang; Li, Albert P.


Book ID
120010939
Publisher
John Wiley & Sons, Inc.
Year
2009
Weight
893 KB
Category
Article
ISBN
047028174X

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Role of drug metabolism in drug discover
โœ Gondi N. Kumar; Sekhar Surapaneni ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 300 KB ๐Ÿ‘ 1 views

## Abstract Metabolism by the host organism is one of the most important determinants of the pharmacokinetic profile of a drug. High metabolic lability usually leads to poor bioavailability and high clearance. Formation of active or toxic metabolites will have an impact on the pharmacological and t