𝔖 Bobbio Scriptorium
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RNA interference against hypoxia inducible factor-1α inhibited growth of cervical cancer by limiting vascularization

✍ Scribed by Yanxiang Cheng; Li Hong; Xuexian Xu; Wen Fan


Book ID
106315125
Publisher
Springer
Year
2010
Tongue
English
Weight
637 KB
Volume
9
Category
Article
ISSN
1610-1979

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## Abstract In oxygenated cells, hypoxia‐inducible factor‐1 (HIF‐1) α subunits are rapidly degraded by a mechanism that involves ubiquitination by the von Hippel–Lindau tumor suppressor E3 ligase complex using 2‐oxoglutarate as a substrate. We examined the effect of 2‐oxoglutarate on the production