𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Inhibition of hypoxia inducible factor-1α (HIF-1α) decreases vascular endothelial growth factor (VEGF) secretion and tumor growth in malignant gliomas

✍ Scribed by Randy L. Jensen; Brian T. Ragel; Kum Whang; David Gillespie


Publisher
Springer US
Year
2006
Tongue
English
Weight
638 KB
Volume
78
Category
Article
ISSN
0167-594X

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Cyclic strain influences the expression
✍ Wolf Petersen; Deike Varoga; Thore Zantop; Joachim Hassenpflug; Rolf Mentlein; T 📂 Article 📅 2004 🏛 Elsevier Science 🌐 English ⚖ 785 KB

## Abstract Neovascularization is involved in beneficial and detrimental processes of tendon pathology. We investigated the influence of repetitive motion on the expression of the most important angiogenic factor, the vascular endothelial growth factor (VEGF) in the 3T3 NIH fibroblast cell line an

2-oxoglutarate downregulates expression
✍ Ken Matsumoto; Shigehiko Imagawa; Naoshi Obara; Norio Suzuki; Satoru Takahashi; 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 299 KB

## Abstract In oxygenated cells, hypoxia‐inducible factor‐1 (HIF‐1) α subunits are rapidly degraded by a mechanism that involves ubiquitination by the von Hippel–Lindau tumor suppressor E3 ligase complex using 2‐oxoglutarate as a substrate. We examined the effect of 2‐oxoglutarate on the production