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Betulinic acid inhibits the expression of hypoxia-inducible factor 1α and vascular endothelial growth factor in human endometrial adenocarcinoma cells

✍ Scribed by Ewa Karna; Lukasz Szoka; Jerzy A. Palka


Publisher
Springer
Year
2010
Tongue
English
Weight
254 KB
Volume
340
Category
Article
ISSN
0300-8177

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## Abstract In oxygenated cells, hypoxia‐inducible factor‐1 (HIF‐1) α subunits are rapidly degraded by a mechanism that involves ubiquitination by the von Hippel–Lindau tumor suppressor E3 ligase complex using 2‐oxoglutarate as a substrate. We examined the effect of 2‐oxoglutarate on the production