2-oxoglutarate downregulates expression
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Ken Matsumoto; Shigehiko Imagawa; Naoshi Obara; Norio Suzuki; Satoru Takahashi;
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Article
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2006
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John Wiley and Sons
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English
⚖ 299 KB
## Abstract In oxygenated cells, hypoxia‐inducible factor‐1 (HIF‐1) α subunits are rapidly degraded by a mechanism that involves ubiquitination by the von Hippel–Lindau tumor suppressor E3 ligase complex using 2‐oxoglutarate as a substrate. We examined the effect of 2‐oxoglutarate on the production