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A Radicicol Derivative, KF58333, Inhibits Expression of Hypoxia-inducible Factor-1α and Vascular Endothelial Growth Factor, Angiogenesis and Growth of Human Breast Cancer Xenografts

✍ Scribed by Kurebayashi, Junichi ;Otsuki, Takemi ;Kurosumi, Masafumi ;Soga, Shiro ;Akinaga, Shiro ;Sonoo, Hiroshi


Book ID
108582080
Publisher
Wiley (Blackwell Publishing)
Year
2001
Tongue
English
Weight
272 KB
Volume
92
Category
Article
ISSN
0910-5050

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## Abstract In oxygenated cells, hypoxia‐inducible factor‐1 (HIF‐1) α subunits are rapidly degraded by a mechanism that involves ubiquitination by the von Hippel–Lindau tumor suppressor E3 ligase complex using 2‐oxoglutarate as a substrate. We examined the effect of 2‐oxoglutarate on the production