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RNA as a Drug Target: The Case of Aminoglycosides

✍ Scribed by Quentin Vicens; Eric Westhof


Publisher
John Wiley and Sons
Year
2003
Weight
50 KB
Volume
34
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

For Abstract see ChemInform Abstract in Full Text.


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Aminoglycosides are a structurally diverse family of aminosugar and aminocyclitol derivatives that are currently the only well-characterized class of small molecules that selectively bind RNA, [1] including sites on prokaryotic 16S rRNA which is believed to be the locus of aminogylcoside antibiotic