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Evaluation of Bacterial RNase P RNA as a Drug Target.

โœ Scribed by Dagmar K. Willkomm; Heike Gruegelsiepe; Olga Goudinakis; Rosel Kretschmer-Kazemi Far; Rolf Bald; Volker A. Erdmann; Roland K. Hartmann

Publisher
John Wiley and Sons
Year
2003
Weight
51 KB
Volume
34
Category
Article
ISSN
0931-7597

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## Abstract For Abstract see ChemInform Abstract in Full Text.

Synthesis and biological evaluation of p
Synthesis and biological evaluation of p-bromospiperone as potential neuroleptic drug
โœ C. C. Huang; A. M. Friedman; R. So; M. Simonovic; H. Y. Meltzer ๐Ÿ“‚ Article ๐Ÿ“… 1980 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 369 KB

p-Bromospiperone was prepared from the reaction of spiperone with bromine. It was tested for dopamine receptor binding affinity in vitro and its ability to stimulate prolactin secretion in vivo. The results indicate no significant change of biological activities due to the bromination of spiperone.