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RNA as a Drug Target: The Case of Aminoglycosides

✍ Scribed by Quentin Vicens; Eric Westhof

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
166 KB
Volume
4
Category
Article
ISSN
1439-4227

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Aminoglycosides are a structurally diverse family of aminosugar and aminocyclitol derivatives that are currently the only well-characterized class of small molecules that selectively bind RNA, [1] including sites on prokaryotic 16S rRNA which is believed to be the locus of aminogylcoside antibiotic