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Design of Small Molecules That Recognize RNA: Development of Aminoglycosides as Potential Antitumor Agents That Target Oncogenic RNA Sequences

✍ Scribed by Steven J. Sucheck; William A. Greenberg; Thomas J. Tolbert; Chi-Huey Wong

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 129 KB
Volume: 39
Category: Article
ISSN: 0044-8249
DOI: 10.1002/(sici)1521-3773(20000317)39:6<1080::aid-anie1080>3.0.co;2-b

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Design of Small Molecules That Recognize RNA: Development of Aminoglycosides as Potential Antitumor Agents That Target Oncogenic RNA Sequences

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Aminoglycosides are a structurally diverse family of aminosugar and aminocyclitol derivatives that are currently the only well-characterized class of small molecules that selectively bind RNA, [1] including sites on prokaryotic 16S rRNA which is believed to be the locus of aminogylcoside antibiotic

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