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ChemInform Abstract: Design of Small Molecules that Recognize RNA: Development of Aminoglycosides [cf. (I) and (II)] as Potential Antitumor Agents that Target Oncogenic RNA Sequences.

✍ Scribed by Steven J. Sucheck; William A. Greenberg; Thomas J. Tolbert; Chi-Huey Wong

Publisher
John Wiley and Sons
Year
2010
Weight
30 KB
Volume
31
Category
Article
ISSN
0931-7597

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Design of Small Molecules That Recognize
Design of Small Molecules That Recognize RNA: Development of Aminoglycosides as Potential Antitumor Agents That Target Oncogenic RNA Sequences
✍ Stevenβ€…J. Sucheck; Williamβ€…A. Greenberg; Thomasβ€…J. Tolbert; Chi-Huey Wong πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 129 KB πŸ‘ 1 views

Aminoglycosides are a structurally diverse family of aminosugar and aminocyclitol derivatives that are currently the only well-characterized class of small molecules that selectively bind RNA, [1] including sites on prokaryotic 16S rRNA which is believed to be the locus of aminogylcoside antibiotic