Synthesis and biological evaluation of p-bromospiperone as potential neuroleptic drug

✍ Scribed by C. C. Huang; A. M. Friedman; R. So; M. Simonovic; H. Y. Meltzer

• Publisher: John Wiley and Sons
• Year: 1980
• Tongue: English
• Weight: 369 KB
• Volume: 69
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600690835

✦ Synopsis

p-Bromospiperone was prepared from the reaction of spiperone with bromine. It was tested for dopamine receptor binding affinity in vitro and its ability to stimulate prolactin secretion in vivo. The results indicate no significant change of biological activities due to the bromination of spiperone.