Risk factors for urinary bladder carcinoma in postmenopausal women : The Iowa Women's Health Study

✍ Scribed by Apeksha Tripathi; Aaron R. Folsom; Kristin E. Anderson

• Publisher: John Wiley and Sons
• Year: 2002
• Tongue: English
• Weight: 87 KB
• Volume: 95
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/cncr.10975

✦ Synopsis

Background:

We evaluated prospectively the association of smoking and other potential risk factors with bladder carcinoma incidence in postmenopausal women.

Methods:

A total of 37,459 women participating in the iowa women's health study completed baseline questionnaires in 1986 and were followed 13 years for bladder carcinoma incidence (n = 112).

Results:

Adjusted for potential confounders, the relative risk (rr) of bladder carcinoma in women who were current smokers compared with those who had never smoked was 3.58 (95% confidence interval [ci] = 1.86-6.88). the rr declined as years since quitting increased. currently, married women, compared with unmarried women, had a rr of 0.66 (95% ci = 0.44-0.99). a 2.46-fold (95% ci = 1.32-4.59) increase in bladder carcinoma risk was identified for women who reported, versus did not report, diabetes. regular versus no physical activity (rr = 0.66, 95% ci 0.43-1.01) and body mass index were inversely associated (p = 0.06) with bladder carcinoma incidence.

Conclusions:

We confirmed that cigarette smoking is an important risk factor for bladder carcinoma in women; women who had quit smoking had a reduction of risk. we also identified diabetes as a potential risk factor, which may invite more research on its role in the development of urinary bladder carcinoma.