Better breast cancer survival for postmenopausal women who are less overweight and eat less fat. The Iowa women's health study
✍ Scribed by Shumin Zhang; Aaron R. Folsom; Thomas A. Sellers; Lawrence H. Kushi; John D. Potter
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 750 KB
- Volume
- 76
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
✦ Synopsis
Background. The authors sought to determine whether prediagnosis obesity, body-fat distribution, and dietary intake of fats, antioxidants, and fiber may be related to survival after the diagnosis of breast cancer.
Methods. The mortality rates of 698 postmenopausal patients with unilateral breast cancer in a large cohort study were analyzed. Body-mass index, waist-to-hip ratio, and food-frequency data were collected by questionnaire within 6 years before breast cancer was diagnosed.
Results. Adjusted for age, women in the highest tertile of body mass index had a 1.9-fold higher risk (95% confidence interval = 1.0-3.7) of dying after breast cancer than those in the lowest tertile; adjusted for other prognostic variables (age, smoking, education level, extent of breast cancer, and tumor siize), this relative risk was 1.5 (95% CI = 0.7 to 2.91. Waist-to-hip ratio was not related to risk of dying norlwas intake of fiber or several dietary antioxidants. Independent of other prognostic variables, risk of death after breast cancer was statistically significantly elevated, with a relative risk greater than 2.0 for the highest tertiles of total ftat, saturated fat, and monounsaturated fat intake, expressed as grams per day. An adjustment for energy intake, which also was associated positively with fatality, weakened these associations somewhat.