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Rheological stability of a procaine penicillin G suspension

โœ Scribed by James C. Boylan; Robert L. Robison

Publisher
John Wiley and Sons
Year
1968
Tongue
English
Weight
174 KB
Volume
57
Category
Article
ISSN
0022-3549

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Chromatographic systems are described which are suitable for the examination of procaine penicillin G preparations which may contain, in addition to procaine and penicillin G, the degradation products paminobenzoic acid, ethyl p-aminobenzoate, benzylpenicilloic acid, and benzylpenillic acid. Further

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Quantitative studies were made o n the effects of various additives such as procaine hydrochloride, dextrose, and citrate in reducing penicillin G procaine solubility in water. Aqueous vehicles were prepared i n which the solubility was lowered to a minimum of 0.036 mg./cc. at room temperature. ONG