Drugs and the liver. Part III: Ageing of
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Ken Woodhouse
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Article
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1992
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John Wiley and Sons
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English
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The clearance of many drugs by the liver is reduced in the elderly, and this accounts, at least in part, for the greater frequency of adverse drug reactions in this population. Ageing in experimental animals is accompanied by a decline in the activities of certain microsomal monooxygenase enzymes;