The biotransformation of motexafin gadolinium (MGd, Xcytrin 1 ) was investigated in subcellular rat and human liver fractions. Microsomal MGd metabolism was dependent on NADPH in both species. Cytosolic metabolism in rat and human livers was dependent on NADPH or NADH. Under anaerobic conditions, MG
Regulation of drug-metabolizing enzymes during the perinatal period in rat and human liver
โ Scribed by Thierry Cresteil
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 705 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0265-9247
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract Primary cultures of human hepatocytes and hepatoma cell line HepG2 are frequently used to evaluate the hepatic disposition of drugs and other xenobiotics. To check the variability of the expression of drugโmetabolizing enzymes in these in vitro models, expression of genes coding for sev
Thrombin is generated during tissue damage in several organs, including the liver, and participates in the process of tissue repair through proteolytic activation of a specific thrombin receptor (TR). The aim of this study was to investigate TR expression in human liver by immunohistochemistry and i
In the process of isolated single liver cells coming together to form three-dimensional spheroids, cells undergo dramatic environmental changes. How liver cells respond to these changes has not been well studied before. This study characterized the functional and biochemical changes during liver sph