The cellular and subcellular localization and mechanism of transport of the heteromeric organic solute transporter (OST) OSTalpha-OSTbeta was examined in human and rodent epithelia. The two subunits of the transporter were expressed together in human small intestine, kidney, and liver, tissues that
Expression and regulation of the bile acid transporter, OSTα-OSTβ in rat and human intestine and liver
✍ Scribed by Ansar A. Khan; Edwin C. Y. Chow; Robert J. Porte; K. Sandy Pang; Geny M. M. Groothuis
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 560 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0142-2782
- DOI
- 10.1002/bdd.663
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The regulatory responses of bile acid (BA) transport in the terminal ileum to perturbations in BA homeostasis are complex, and conflicting results have been reported by different investigators. These studies were designed to examine the response of this system to a reduction in ileal bile salt conce
Dietary fatty acid (FA) absorption across the gastrointestinal (GI) tract is of critical importance for sustenance, however, excessive FA absorption has also been linked to metabolic syndrome and associated disorders. The expression of isoforms that regulate the dietary FA absorption are not as well
The integrin ␣91 is one of the recently identified integrins whose expression is restricted to specialized tissues. Its exact function is still unknown. In the present study, we have analyzed the expression of the ␣9 subunit in human fetal and adult small intestinal and colonic epithelia as well as
The gene encoding cholesterol 7␣-hydroxylase (CYP7A1) is tightly regulated to control bile acid synthesis and maintain lipid homeostasis. Recent studies in mice suggest that bile acid synthesis is regulated by the fasted-to-fed cycle, and fasting induces CYP7A1 gene expression in parallel to the ind