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Restricted T cell receptor usage in DA rats during early collagen-induced arthritis

✍ Scribed by Helena Erlandsson; Åsa Müsseneru; Lars Klareskogu; Daniel P. Goldf

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
402 KB
Volume
24
Category
Article
ISSN
0014-2980

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✦ Synopsis

T cell receptor usage in DA rats with collagen-induced arthritis 1929

Restricted T cell receptor usage in DA rats during early collagen-induced arthritis*

We have investigated the usage of T cell receptor (TcR) V$ gene structures in DA rats undergoing homologous collagen-induced arthritis induced by immunization with homologous collagen type I1 emulsified in Freund's incomplete adjuvant. TcR Vf3 expression within freshly isolated inflamed synovial tissue (ST) and primary draining lymph nodes was analyzed in a semi-quantitative polymerase chain reaction assay. A highly restricted TcR Vf3 gene expression was observed in STSamples 2 days after onset of clinical disease, withVf36,8.2 and 8.5 comprising more than 60 % of the total V$ expression measured.The corresponding primary draining lymph nodes from the diseased animals showed some bias in V$ expression at this time but not as remarkable as that found in ST. One week after onset of disease, consistent V$ gene bias was much less evident in either site.

These results indicate that T cells which infiltrate synovia early in disease are highly restricted with respect to V$ expression.

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