Relative importance of CD4+ and CD8+ T cell repertoires in the development of acute graft-versus-host disease in a murine model of bone marrow transplantation
β Scribed by Miconnet, I; de La Selle, V; Bruley-Rosset, M
- Book ID
- 110010458
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 85 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0007-1188
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In vitro depletion of mature pan-T lymphocytes has been widely and successfully used to prevent acute graft-versus-host disease (GVHD) after allogeneic bone-marrow transplantation (BMT). However, this procedure has been associated with a high incidence of graft failure and leukemic relapse. In this
Patients undergoing bone marrow transplantation are at high risk of developing acute graft-versus-host disease (GVHD) which is a primary limiting factor for this procedure inasmuch as it is responsible for high morbidity rates and is associated with poor survival outcome. To provide improved treatme