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CD8+ cytotoxic T cell repertoire implicated in graft-versus-leukemia effect in a murine bone marrow transplantation model

✍ Scribed by de La Selle, V; Riché, N; Dorothé, G; Bruley-Rosset, M


Book ID
110011018
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
80 KB
Volume
23
Category
Article
ISSN
0007-1188

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Selective depletion of marrow-T cytotoxi
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In vitro depletion of mature pan-T lymphocytes has been widely and successfully used to prevent acute graft-versus-host disease (GVHD) after allogeneic bone-marrow transplantation (BMT). However, this procedure has been associated with a high incidence of graft failure and leukemic relapse. In this