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Prevention of graft-versus-host disease in high risk patients by depletion of CD4+ and reduction of CD8+ lymphocytes in the marrow graft

✍ Scribed by Herrera, C; Torres, A; García-Castellano, J M; Roman, J; Martin, C; Serrano, J; Falcon, M; Alvarez, M A; Gomez, P; Martinez, F


Book ID
110010789
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
75 KB
Volume
23
Category
Article
ISSN
0007-1188

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Selective depletion of marrow-T cytotoxi
✍ D. Maraninchi; C. Mawas; D. Guyotat; J. Reiffers; J. P. Vernant; N. Gratecos; J. 📂 Article 📅 1988 🏛 Springer 🌐 English ⚖ 418 KB

In vitro depletion of mature pan-T lymphocytes has been widely and successfully used to prevent acute graft-versus-host disease (GVHD) after allogeneic bone-marrow transplantation (BMT). However, this procedure has been associated with a high incidence of graft failure and leukemic relapse. In this