𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Relationship between spatial structure and pharmacological activity of a series of β-adrenomimetics

✍ Scribed by B. S. Zhorov; V. A. Govyrin

Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
455 KB
Volume
16
Category
Article
ISSN
0020-7608

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

All equilibrium conformations of a series of N‐alkyl‐α‐alkyl derivatives of noradrenaline and their synthetic precursors—phenylaminoketones—have been calculated. It has been shown that spasmodic changes in bronchodilating activity of the catecholamines, observed with the increase in α‐alkyl substituent size, may arise from the difference in the ratio of diastereoisomers produced by reduction of aminoketones.

📜 SIMILAR VOLUMES

Relationship between fungistatic activit
Relationship between fungistatic activity and structure in a series of simple aromatic compounds
✍ Cavill, G. W. K. ;Phillips, J. N. ;Vincent, J. M. 📂 Article 📅 1949 🏛 Wiley (John Wiley & Sons) ⚖ 594 KB

## Abstract The fungistatic activity of 127 benzene derivatives is reported and their behaviour related to structure and, in less detail, to solubility. The aromatic nucleus is more effective than its saturated counterpart. The effect of hydrophilic and nitro groups substituted in the benzene ring

Structure activity relationship of four
Structure activity relationship of four tetrahydrocannabinols and the pharmacological activity of five semi-purified extracts ofCannabis sativa
✍ E. A. Carlini; M. Santos; U. Claussen; D. Bieniek; F. Korte 📂 Article 📅 1970 🏛 Springer 🌐 English ⚖ 528 KB

The structure activity relationships of four tetrahydroeannabinols and the pharmacological activity of five semi-purified extracts from Cannabis sativa were studied using four biological methods: corneal areflexia in rabbits (Gayer test) and eatatonia, decrease of motor activity and suppression of i