Structure activity relationship of four tetrahydrocannabinols and the pharmacological activity of five semi-purified extracts ofCannabis sativa
✍ Scribed by E. A. Carlini; M. Santos; U. Claussen; D. Bieniek; F. Korte
- Publisher
- Springer
- Year
- 1970
- Tongue
- English
- Weight
- 528 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0033-3158
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✦ Synopsis
The structure activity relationships of four tetrahydroeannabinols and the pharmacological activity of five semi-purified extracts from Cannabis sativa were studied using four biological methods: corneal areflexia in rabbits (Gayer test) and eatatonia, decrease of motor activity and suppression of isolation-induced aggressiveness in mice. Modifications in the structure of pure, natural A'-THC rendered the resultant compounds inactive only when activity was measured by the Gayer test; by the other three methods the activity ranged from 1/sth to equal to the activity of pure A"-THC. It was concluded that of the methods employed, the Gayer test was the only useful procedure to measure AP-THC content in mixtures. This was confirmed by the relationship found between A 9-THC content and activity using five semi-purified extracts.