In eukaryotes, progression of the cell cycle is associated with periodic transcription activation/repression of growth-regulatory genes. We summarize here current knowledge and views on the role of critical cell-cycle regulators such as the retinoblastoma pocket family members and cyclin-dependent k
โฆ LIBER โฆ
Regulation of transcription by proteins that control the cell cycle
โ Scribed by Dynlacht, Brian D.
- Book ID
- 109796416
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 188 KB
- Volume
- 389
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/38225
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The product of the retinoblastoma gene ( R B I ) is believed to function as a negative regulator of cell growth. Recent experimental results suggest that RBI may exert its growth-suppressing activity by regulating the transcription of a variety of growthrelated genes, including FOS, MYC, and TGFB /.