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The role of BRCA1 in transcriptional regulation and cell cycle control

✍ Scribed by Mullan, P B; Quinn, J E; Harkin, D P

Book ID
110071879
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
165 KB
Volume
25
Category
Article
ISSN
0950-9232

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BRCA1 was the first breast cancer susceptibility gene to be identified and cloned. In individuals from high-risk families, mutations in BRCA1 increase the lifetime risk of developing breast cancer eight to tenfold, compared to the general population. How the BRCA1 protein product normally functions