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Role of BRCA1 and BRCA2 as regulators of DNA repair, transcription, and cell cycle in response to DNA damage

✍ Scribed by Kiyotsugu Yoshida; Yoshio Miki

Book ID
108582353
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
140 KB
Volume
95
Category
Article
ISSN
1347-9032

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## Abstract Mutations of BRCA1 gene are associated with more than half the cases of hereditary breast cancer. Breast cancer formation in BRCA1 mutation carriers is generally accompanied by loss of the wild‐type allele, suggesting that BRCA1 protein may function as a tumor suppressor. The human BRCA