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Transcriptional control by cell-cycle regulators: A review

โœ Scribed by Luigi Lania; Barbara Majello; Giuliana Napolitano

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
200 KB
Volume
179
Category
Article
ISSN
0021-9541

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โœฆ Synopsis

In eukaryotes, progression of the cell cycle is associated with periodic transcription activation/repression of growth-regulatory genes. We summarize here current knowledge and views on the role of critical cell-cycle regulators such as the retinoblastoma pocket family members and cyclin-dependent kinases in the regulation of gene transcription. In particular, we discuss here the role of specific cyclin-dependent kinase complexes in the regulation of basal transcription. Although the functional connections between transcription and cell-cycle regulators is far from being understood, recent progress has been made in connecting cell-cycle progression to dedicated components of the RNA polymerase II transcription apparatus complex.

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