✦ LIBER ✦

Regulation of transcription by the retinoblastoma protein

✍ Scribed by Jonathan M. Horowitz

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 908 KB
Volume: 6
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870060211

No coin nor oath required. For personal study only.

✦ Synopsis

The product of the retinoblastoma gene ( R B I ) is believed to function as a negative regulator of cell growth. Recent experimental results suggest that RBI may exert its growth-suppressing activity by regulating the transcription of a variety of growthrelated genes, including FOS, MYC, and TGFB /. A series of biochemical and molecular analyses suggest that RBI indirectly affects gene expression via cell-cycle-regulated interactions with transcription factors, such as E2F and SP I. Determination of the mechanisms regulating such protein-protein interactions and the identification of additional targets of RB I function will provide vital insights into the role of this tumor-suppressor gene in mammalian cell proliferation. Genes Chrorn Cancer 6:124-/3/ ( I 993).

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