✦ LIBER ✦

Transcriptional control of vitamin D-regulated proteins

✍ Scribed by Jane B. Lian; Gary S. Stein

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 913 KB
Volume: 49
Category: Article
ISSN: 0730-2312
DOI: 10.1002/jcb.240490108

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✦ Synopsis

Vitamin D is a physiological regulator of gene transcription associated with control of a broad spectrum of biological processes that include but is not restricted to growth, differentiation and calcium-mediated homeostatic control. Transcriptional regulation is mediated by sequence-specific interactions of a 1 ,25(0H)2D3-vitarnin D receptoraccessory factor complex with vitamin D responsive elements (VDRE) residing in the promoters of hormone responsive genes. Functioning primarily as a transcription enhancer, activity at the VDRE is controlled by diverse and integrated cellular signalling pathways acting synergistically and/or antagonistically with a series of basal regulatory elements and other hormone regulated sequences that are components of modularly organized vitamin D-responsive gene promoters. Molecular mechanisms that integrate the activities at promoter elements contributing to vitamin D-related transcriptional control include overlapping transcription factor binding domains within regulatory elements and cooperative activities at independent regulatory sequences that determine the level of vitamin D responsiveness. D 1992 Wiley-Liss, Inc.

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