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Regulation of ribosomal RNA methylation in a temperature-sensitive mutant of BHK cells

✍ Scribed by OUELLETTE, ANDRE J.; BANDMAN, EVERETT; KUMAR, AJIT


Book ID
109702058
Publisher
Nature Publishing Group
Year
1976
Tongue
English
Weight
357 KB
Volume
262
Category
Article
ISSN
0028-0836

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## Abstract A temperature‐sensitive growth mutant derived from the BHK 21 cell Line, ts AF8, was found to have greatly reduced DNA synthesis at the nonpermissive temperature. This reduction is mainly due to a decrease in the frequency of cells synthesizing DNA. Upon shift up, ts AF8 becomes blocked

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## Abstract Three different temperature sensitive mutants derived from the Syrian hamster cell line BHK 21 were found to have greatly reduced DNA synthesis at the non‐permissive temperature. These mutants are distinct by complementation analysis and behave at the non‐permissive temperature as cell