Regulation of Ribonucleotide Reductase during Iron Limitation
✍ Scribed by Alexandra Seguin; Diane McVey Ward; Jerry Kaplan
- Book ID
- 116755129
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 137 KB
- Volume
- 44
- Category
- Article
- ISSN
- 1097-2765
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📜 SIMILAR VOLUMES
Mammalian ribonucleotide reductase catalyzes the rate-limiting for the de novo synthesis 2'-deoxyribonucleoside 5'-triphosphates. There is some suggestion that this step may also be the rate-limiting step of DNA synthesis. It is apparent that the level of the enzyme, ribonucleotide reductase, varies
Kihonucleotide reductase (RNR) catalyzes the rate limiting step in the production of deoxyribonucleotides needed for DNA synthesis. In addition to the well documented allosteric regulation, the synthesis of the enzyme is also tightly regulated at the level of transcription. niRNAs for both subunits