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Regulation of non-muscle myosin structure and function

✍ Scribed by Sandra Citi; John Kendrick-Jones

Publisher: John Wiley and Sons
Year: 1987
Tongue: English
Weight: 663 KB
Volume: 7
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.950070404

No coin nor oath required. For personal study only.

✦ Synopsis

In vertebrate and invertebrate nonmuscle myosins, light-and heavy-chain phosphorylation regulate myosin assembly into filaments, and interaction with actin. Vertebrate non-muscle myosins can exist in vitro in three main states, either 'folded ' (assembly-blocked) or ' extended' (assembly-competen t) monomers, and $laments. Light-chain phosphorylation regulates the ' dynamic equilibrium' between these states. The ability of the myosin to undergo changes in conformation and state of assembly may be an important mechanism in regulating the organization of the cytoskeleton and cell motility.

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