𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Afferent-inherent regulation of myosin heavy chain isoforms in rat muscle spindles

✍ Scribed by Jon M. Walro; Jun Wang; Gina M. Story

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
328 KB
Volume
20
Category
Article
ISSN
0148-639X

No coin nor oath required. For personal study only.

✦ Synopsis

Whether afferents exert their morphogenetic influence on spindles through release of trophic factors at intrafusal fiber junctions or via participation in proprioceptive pathways which modulate the motor activity to muscles was investigated by comparing myosin heavy chain (MHC) expression in intrafusal fibers after ablation of afferents (deafferentation, or DA) to the extensor digitorum longus (EDL) of adult rats or after ablation of the corresponding central processes of afferents to the spinal cord (central-process ablation, or CPA). DA and CPA elicited an exaggerated pedal plantarflexion, and hypertrophy of the EDL concomitant with atrophy of the soleus in the affected hindlimb. Frequencies and patterns of expression of seven MHCs expressed by intrafusal fibers in CPA muscles were indistinguishable from normal rats. However, frequencies and patterns of expression of several MHCs were abnormal following DA. Thus factors transported anterogradely from afferents to intrafusal fibers may regulate MHC expression in intrafusal fibers.

πŸ“œ SIMILAR VOLUMES

Lack of type 1 and type 2A myosin heavy
Lack of type 1 and type 2A myosin heavy chain isoforms in rat slow muscle regenerating during chronic nerve block
✍ Menotti Midrio; Daniela Danieli-Betto; Alessandra Esposito; Aram Megighian; Ugo πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 413 KB

The degeneration-regeneration process was induced by bupivacaine injection in innervated, denervated, and nerve-blocked rat soleus muscles. Nerve block was obtained by superfusion of the sciatic nerve with tetrodotoxin (TTX). Two weeks after bupivacaine injection, immunohistochemical and electrophor

Increase in the degree of coexpression o
Increase in the degree of coexpression of myosin heavy chain isoforms in skeletal muscle fibers of the very old
✍ Jesper L. Andersen; Gerasimos Terzis; Ann Kryger πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 187 KB πŸ‘ 2 views

Myosin heavy chain (MHC) isoform composition was determined in 2264 single skeletal muscle fibers from vastus lateralis muscle of a group (n = 12) of very old subjects (average age, 88 years). The number of fibers containing only MHC I, IIA, or IIX was 19.9%, 27.2%, and 0.3%, respectively. Surprisin

Proportions of slow myosin heavy chain-p
Proportions of slow myosin heavy chain-positive fibers in muscle spindles and adjoining extrafusal fascicles, and the positioning of spindles relative to these fascicles
✍ Alfred Maier πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 329 KB πŸ‘ 2 views

Chicken leg muscles were examined to calculate the percentages of slow myosin heavy chain (MHC)-positive fibers in spindles and in adjacent extrafusal fascicles, and to clarify how the encapsulated portions of muscle spindles are positioned relative to these fascicles. Unlike mammals, in chicken leg

Differential expression of myosin heavy
Differential expression of myosin heavy chain mRNA and protein isoforms in four functionally diverse rabbit skeletal muscles during pre- and postnatal development
✍ Godfrina Mckoy; Marie-Eva LΓ©ger; Francis Bacou; Geoffrey Goldspink πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 260 KB πŸ‘ 2 views

Myosin heavy chains (hcs) are the major determinant in the speed of contraction of skeletal muscle, and various isoforms are differentially expressed depending on the functional activity of the muscle. Using the rapid amplification of cDNA ends (3Ј RACE) method, we have characterised the 3Ј end of t