✦ LIBER ✦

Steroid-hormone regulation of myosin subunit expression in smooth and cardiac muscle

✍ Scribed by Tanja Calovini; Hannelore Haase; Ingo Morano

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 890 KB
Volume: 59
Category: Article
ISSN: 0730-2312
DOI: 10.1002/jcb.240590109

No coin nor oath required. For personal study only.

✦ Synopsis

We investigated the effects of ovarectomy and the steroid hormones estrogen and testosterone on the in vivo expression of heavy (MHC) and light (MLC) chains of myosin in the heart, uterus, and aorta of rats. In the heart, ovarectomy decreased alpha-MHC expression, while both steroid hormones normalized it. Differential steroid hormone effects could be observed on myosin subunit expression of smooth muscle. Testosterone but not estrogen normalized the ovarectomy-induced decreased expression of SMI and strongly increased the expression of 5'4nserted MHC in the uterus. Estrogen but not testosterone normalized the ovarectomy-induced diminished MLCl7a expression. In contrast to the uterus, no steroid hormone effects on myosin subunit expression could be observed in the aorta.

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